Ranibizumab is a therapeutic antibody fragment designed specifically for treating
degenerative conditions of the eye.

India-based Intas is the first company globally, to develop and launch a biosimilar
version of ranibizumab.

RAZUMAB is manufactured under strict guidelines for sterile use in the eye and is offered as single dose vial, thus reducing the risk of contamination during use.

Ranibizumab blocks the production of vascular endothelial cell growth factor A (VEGF-A), a protein which when overexpressed leads to abnormal blood vessel growth in the retina, that can cause leaks and vision loss.

Ranibizumab is indicated for the treatment of Neovascular (Wet) Age-related Macular Degeneration (AMD), a common degenerative condition of the eyes in the elderly. It is also indicated for Macular Edema following Retinal Vein Occlusion (RVO), Diabetic Macular Edema (DME), Diabetic Retinopathy in patients with Diabetic Macular Edema and vision loss resulting from choroidal neovascularization in pathologic myopia (mCNV).

"Intas' ranibizumab, RAZUMAB is a 100 percent 'Made In India' molecule, a feat achieved by scientists at Intas and unparalleled till date. With the mission to provide global healthcare at affordable costs, RAZUMAB will be about 25 percent cheaper than the imported Lucentis in the hand of the patient. This would lead to an annual saving of about Rs 35,000 or more in the cost of treatment to the patient, depending on the number of injections used and the clinical condition of the patient. Our objective is to make the treatment available to a wider patient pool, that is as yet denied treatment due to high cost of imported Lucentis," said Mr Binish Chudgar, vice chairman, Intas Pharma.

RAZUMAB is the tenth biosimilar launched by Intas in India, by far the largest number
of indigenously developed biosimilars by any company.

Since 2004, when Intas launched its first biosimilar, Intas has constantly worked to bring the latest in biological therapies to Indian patients at affordable prices.

With its robust pipeline of future products under development, Intas aims to continue on this endeavor. Till date, Intas is also the only company from India to have launched a biosimilar in the highly regulated European market and is also the only company from India to have two of its biosimilars filed for registration in the US.

Its first biosimilar for global markets, Accofil (filgratsim) was launched in Europe earlier this year.

The company expects to launch its first biosimilar in the US within the next 9-12 months.

Intas' manufacturing facilities are approved by global regulatory agencies such as EMA, ANVISA, WHO and others.

RAZUMAB is also manufactured in the same facilities as its other biosimilars.