RANK 16
272 crore* |
Shantha Biotech
|
MD
|
Dr KI
Varaprasad Reddy
|
Business |
R&D
and manufacture of human therapeutics |
Start-up
Year: 1993
|
Address:
H.No.5-10-173,
3rd
& 4th Floors, Vasantha Chambers, Fateh Maidan
Road, Basheerbagh,
Hyderabad - 500 004.
|
Tel: +91
40 23234136
|
Fax: +91
40 2323410
|
Website:
www.shanthabiotech.com
|
Shantha Biotech is undeterred by the
setback faced on account of its Shan5 vaccine and is gearing to launch
four new vaccines between 2011-16
![](/IMG/044/47044/16vreddyshantabiotech.jpg)
Shantha Biotech, the first Indian company to
launch an r-DNA vaccine in 1997, witnessed a considerable 19 percent
drop in its revenue — from
![](http://www.biospectrumindia.com/images/content/2010/aug/INR-currency_symbol.jpg)
334.23 crore in 2009-10 to
![](http://www.biospectrumindia.com/images/content/2010/aug/INR-currency_symbol.jpg)
272 crore in
2010-11. The drop in revenue is mainly because Shantha Biotech recalled
its five-in-one vaccine, Shan5, from across the global markets
following emergence of safety concerns.
The WHO, which was procuring the Shan5 vaccine from Shantha Biotech
under a long-time contract worth $340 million, called for recall and
destruction of all the batches of the vaccine after a “white sediment”
was discovered in some of the vials. Shantha Biotech supplied 24
million doses of Shan5 vaccines between November 2008 and February
2010.
However, it is difficult to ascertain how much portion of this supply
has been used. The cost of the 24 million vaccines would be around $72
million, assuming that the WHO pays $3 for a single dose of vaccine.
The WHO, in its July 28, 2010, statement noted that it will maintain
the tetanus toxoid, Shan TT, and hepatitis B vaccine, Shanvac, on the
list of its prequalified products. Also, the prequalification for
evaluation of cholera vaccine, Shancol, will continue. Since the
potential root cause of the appearance of the sediment is linked with
the manufacture of the pertussis component, the WHO has decided to
remove the tetravalent vaccine (DTwP-hepatitis B) from the list of
prequalified products.
The Who has also decided to terminate the ongoing prequalification
evaluation process for a DtwP vaccine, Shantrip.
Shantha Biotech, 80 percent of which is now owned by Sanofi Aventis, is
one of the leading players in the field of modern biotechnology in
India.
Since the development of the recombinant hepatitis B vaccine, the
company has launched a tetravalent DPT hepatitis vaccine and has also
commercialized three therapeutic proteins, including interferon alpha
2b, streptokinase and erythropoietin. Along with its subsidiary,
Shantha West at San Diego, Shantha Biotech
is engaged in the development of monoclonal antibodies using the human
body’s own defense mechanisms.
Realizing the potential of collaborative research, the company
established collaborations with leading institutes like the Center for
Cellular and Molecular Biology, the Indian Institute of Sciences and
the International Vaccine Institute, Korea. Vaccines, therapeutic
proteins and therapeutic monoclonals are the main focus areas of the
firm for R&D in the product segment.
Channeling almost 25 percent of its revenue into research, equipped
with 50,000 sq ft of laboratory area and having facilities for
animal cell culture, hybridoma technology, virus handling, and upstream
and downstream process development, Shantha Biotech boasts of
state-of-the-art R&D infrastructure to engage in research of
infectious diseases and oncology. The company has four vaccines,
including a typhoid vaccine, a measles-rubella vaccine, a rotavirus
vaccine and an HPV vaccine, in its product pipeline for the period of
2011-16.