In continuation with our special
series on CSOs, we bring yet another achiever in the field of
biotechnology, Dr Venkata Ramana who is the Research Director, Reliance
Life Sciences, an expert in vaccines and recombinant proteins.
The recombinant protein area is one of the promising
areas for the future. Researchers believe that recombinant vaccines
could be the answer to many potential diseases.
In India, for the last 10 years, Dr Venkata Ramana has been working
with Reliance Life Sciences (RLS) in the areas of recombinant proteins,
therapeutic monoclonal antibodies, siRNA-based drugs and therapeutic
fusion proteins.
Early years
Dr Venkata Ramana began his career in microbial fermentation research
under the guidance of Prof. NG Karanth and had a chance to apply
chemical engineering principles to biology. After completing PhD in
biochemistry from Central Food and Technology Research Institute
(CFTRI), Mysore, he went to University College London (UCL), London,
UK, and worked in the area of organic biocatalysis where his interest
was to study the properties of enzymes isolated from thermostable
microorganisms, and their action in organic solvents. He worked for
three years at UCL before returning to India.
On his return, he joined Shantha Biotech and worked for seven years on
various projects including Shantha’s most productive project, the
development of recombinant hepatitis B vaccine.
Activities at Reliance
Currently Dr Ramana is involved in a number of projects at Reliance.
There are many biosimilar recombinant proteins and monoclonal
antibodies, that are in various stages of development. Commenting on
this, Dr Ramana said, “The siRNA is one of the focus areas for Reliance
Life Sciences. We are evaluating a number of anti-viral and anti-cancer
siRNAs in in-vitro and animal models. Research on novel
monoclonal antibodies and fusion proteins is underway for a number of
indications.”
“Reliance Life Sciences is a research-driven, biotechnology-led, life
sciences organization. The company focuses on key areas such as
medical, plant and industrial biotechnology. The company gives emphasis
to biopharmaceuticals, pharmaceuticals, clinical research services,
regenerative medicine, molecular medicine, novel therapeutics,
biofuels, plant biotechnology and industrial biotechnology,” adds
Dr Ramana.
RLS has the largest biosimilars pipeline in the industry. Regarding the
product launches, he says, “The company has launched four biosimilars
in the market – ReliFeron (Recombinant Interferon α) ReliPoietin
(Recombinant Erythropoietin), ReliGrast (Recombinant Granulocyte colony
stimulating factor) and MIRel (Recombinant Reteplase - tissue
plasminogen activator).”
Dr Ramana firmly believes that there are very good opportunities in the
area of recombinant proteins. Commenting on the future, he says, “In
the area of recombinant proteins, we can expect modified versions. They
could be PEGylated, fused to other proteins and mutagenized at various
sites, thus exhibiting better phamacokinetic and pharmacodynamic
properties. We can also expect natural proteins expressed as
recombinant proteins. In the area of vaccines, we will see vaccines
developed based on proteomics approach and which elicit T-cell
response.”
Innovation drives growth
According to Dr Ramana, the Indian biotechnology industry has made
impressive progress in the area of vaccines and it constitutes a
significant amount of exports. He says, “The industry is also trying to
replicate such a success story in the area of biopharmaceuticals with
substantial investment in research and facilities.”
The Indian industry has to watch the regulatory environment both in
India and outside. He adds, “Meeting the requirements of new guidelines
would require completely new mindset from quality standpoint and
manufacturing practices. The industry also needs trained manpower to
meet these challenges.”
Dr Ramana puts innovation as the key to the success of the
biotechnology industry. “While laying stress on the innovation for
growth, we need to embrace new technologies in the area of discovery
and delivery. Collaboration with institutes and academics is a very
important piece in the puzzle of innovation. Also, venture capital
funding for testing proof-of-concept would expedite discovery, which
would catapult industry to the next level pretty much the way it
happened and is still happening in the Western world,” shares Dr Ramana.
Inspiring factors
Dr Ramana is a firm believer of team work. Speaking on his
achievements, he says, “Instead of calling them my achievements, I
would call it the achievements of the teams I have worked with. My
training in CFTRI and UCL have paved the way for my work on projects
like hepatitis B vaccine and interferon alpha at Shantha Biotech. In
Reliance Life Sciences, my team worked on a number of projects, which
has resulted in commercialization of five recombinant proteins
and other projects.”
Dr Ramana who believes that if not a researcher, he would have been a
teacher. “I think the passion and commitment of the companies that I
worked with to develop much-needed life saving drugs is the
inspiration,” he shares.
Dr Ramana also feels fortunate to have good friends who constantly
inspire him. While crediting his friends and family for his success,
while praising his mentor, he observes, “I consider my PhD supervisor,
Prof. Karanth as my mentor. From him, I learnt not only about
practicing science, but also basic ethos of life.”
As India moves ahead towards new technological revolution in next
decade, it is the efforts of scientists like Dr Venkata Ramana that can
play an important role in creating new opportunities in biotechnology
area to tackle the various problems of mankind.