“Quadrupole
LCMS will continue to see robust demands in future”
—Senya
Imamichi, managing director, Shimadzu Analytical (India) Pvt Ltd
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Not long ago Shimadzu pioneered
the introduction of Photodiode array detectors which went on to replace
the conventional UV-VIS detectors in HPLC. The launch of LCMS-2020 in
2009 by Shimadzu heralds a new era in desk top Mass Spectrometric
Detectors for HPLC systems that have the capability to address the most
demanding requirements in pharmaceutical and life sciences. The
development of LCMS 2020 is based on Shimadzu’s proven Mass
Spectrom etry platforms which adopted simple, easy-to-use design while
maintaining superior performance.
Delivering the ultimate in measurement speed and sensitivity, the
compact LCMS-2020 mass spectrometer offers faster measurements and
higher detection sensitivity for quicker and more accurate analysis of
trace impurities, environmental pollutants, and contaminants in
different sample matrices. When combined with a Prominence ultra-fast
LC (UFLC/UFLCXR) the system helps analysts achieve the ultimate in
separation performance and productivity.
The single quadrupole system of LCMS-2020 uses a patented ultrafast(UF)
technology providing significantly higher sensitivity than any other
single quadrupole analyzer and offers unique cost effective solutions
to a range of analytical requirements such as mass identification,
process monitoring, mass based purification etc. The new UFscanning
technology achieves measurement speeds of 15,000 u/sec without
sacrificing sensitivity or resolution, thus obtaining the best
chromatography for the fastest LC conditions.
UFSwitching technology of LCMS-2020 enables switching between positive
and negative ion modes in 15 milliseconds so even the fastest LC peaks
can be analysed in both modes, thus increasing productivity. Innovative
ion optics with the newly developed Qarray ion optical system provide
superior sensitivity, repeatability, and linearity, achieving 50
percent to 300 percent greater sensitivity than any other single
quadrupole analyzer for substances most commonly measured. Users can
inject less and keep the analyzer cleaner, longer.
LCMS-2020 enables improved high mass operation with sensitivity
increased by more than 500 percent for masses above 1,000. In addition
to better performance, the LCMS-2020 allows easier maintenance,
permitting users to replace the ionization unit and inlet capillary to
the MS from the LC, without breaking the vacuum. The ESI method
typically used for LCMS can be replaced with APCI, which is suitable
for neutral compounds, or with a dual ionization source (DUIS) for
simultaneous operation of both ionization modes, quickly and without
tools.
The new Shimadzu LCMS-2020 with its breakthrough technology is the
world’s most sensitive, fastest scanning and fastest polarity
switching single quadrupole mass spectrometric detector available. The
launch of LCMS-2020 recently at Delhi attracted a large number of Mass
Spectroscopists from the Pharmaceutical Industry.
The strength of single quadrupole mass spectrometric detectors lies not
only in their adoption by HPLC users but also by the pharmaceutical
industry as a whole. Applications on DMPK (Drug Metabolism and
Pharmacokinetics) and compound screening are particularly well suited
for single quadrupole LCMS. Besides its high resolution and accuracy,
LCMS is also a high-throughput technique capable of meeting a number of
pharmaceutical industry’s needs from R&D from
analytical services, to method development and quality control. With
increases in Pharmaceutical R&D spending and advancements in
drug development, single quadrupole LCMS will continue to see robust
demands in future.