Biopharmaceutical company Menarini, and its dermatology and aesthetic medicine arm RELIFE have introduced Definisse double needle threads in India. The threads require reduced procedural and recovery time, no general anaesthesia with immediate and visible results leading to higher patient satisfaction. The aesthetic procedure using Definisse double-needle threads results in contouring, lifting, realignment of sagging tissue, and reinforcement of the middle and lower thirds of the face and neck. 

The aesthetic medicine solution is used for supporting and repositioning soft tissue for the cheek, jawline, and eyebrow. When placed under the skin, the barbs open like an umbrella to form a support structure that lifts the sagging skin. 

Definisse threads are made of copolymers of synthetic origin poly(L-lactide-co-ε-caprolactone). The threads were designed to have a barbed tri-dimensional geometry to enable them to maintain a mechanical lifting action for repositioning of sagging facial tissue, and a histological revitalizing action from the stimulation of fibroblasts and the synthesis of collagen, hyaluronic acid and elastin around the threads. The threads can be used to perform three-dimensional tissue repositioning and to provide a noticeable lifting effect for mild to moderate sagging tissue, with results last over 18 months as shown in clinical studies due to the collagen-stimulating properties.