IIT Mandi reinvents implant safety with revolutionary anti-bacterial coating

November 07, 2023 | Tuesday | News

To improve therapeutic outcome and experience of patients undergoing orthopaedic or dental surgeries

Image caption- L-R: Dr Amit Jaiswal, Associate Professor, School of Biosciences and Bioengineering, IIT Mandi, with research scholar Dr Shounak Roy

 

A team of researchers at the Indian Institute of Technology (IIT) Mandi has unveiled an innovative solution to a long-standing problem with medical implants – the risk of infections. A team led by Dr Amit Jaiswal, Associate Professor, School of Biosciences and Bioengineering, IIT Mandi, has introduced an ingenious solution for implant-associated infections by utilising innovative sugar-coated nanosheets as implant coatings.

The research team has devised a biocompatible, non-leaching, and contact-based antibacterial coating for implants, utilising quaternary pullulan functionalised MoS2 (MCP) glycosheets. These cationic MCP glycosheets have been seamlessly applied to the surfaces of polydopamine-modified stainless steel and polyvinyl fluoride substrates through a straightforward electrostatic interaction process.

The developed MCP coating exhibited outstanding anti-bacterial efficacy, effectively eradicating more than 99.5% of Escherichia coli and Staphylococcus aureus bacteria.

A remarkable achievement of this research is that this anti-bacterial performance remains stable for over 30 days without any leaching from the implant surfaces. Furthermore, MCP-coated implants have proven to be entirely safe, inducing neither acute nor sub-chronic toxicity in mammalian cells during both in-vitro and in-vivo testing. 

The researchers are in discussion with orthopaedic hospitals to take it forward for clinical trials.

 

Comments

× Your session has expired. Please click here to Sign-in or Sign-up

Have an Account?

Forgot your password?

First Name should not be empty!

Last Name should not be empty!

Email address should not be empty!

Show Password should not be empty!

Show Confirm Password should not be empty!

Newsletter

E-magazine

Biospectrum Infomercial

Bio Resource

I accept the terms & conditions & Privacy policy