As public private partnerships (PPP)
form the backbone of Indian biotechnology industry - leveraging them
further
can act as a catalyst to boost the
product outcome and commercialization
![](http://www.biospectrumindia.com/images/content/2010/Nov/Teamwork-connection_shutter.jpg)
Having crossed the $3 billion mark in 2009-10, the Indian
biotechnology industry is prepped to achieve significant growth in the
future. For this, the industry is heavily dependent on the country's
innovation infrastructure, and on the significant role of Public
Private Partnerships.
In this regard, Government of India, along with the Department of
Science & Technology has launched various initiatives like INSPIRE
(Innovation in Science Pursuit for Inspired Research), to attract
talent into science. The government is also embarking on a major
multi-billion dollar-initiative model to harness India's innovation
capability. Fifty percent of this is being funded by public private
partnership (PPP). The vision is to catapult the country to one of the
top five pharmaceutical innovation hubs by 2020, with one in every
5-to-10 drugs discovered worldwide, coming from India.
The Department of Biotechnology (DBT) has fostered PPPs to lay their
own infrastructure. Some noteworthy examples of such initiatives are
the Biotechnology Industry Partnership Programme (BIPP) and the Small
Business Innovation & Research Initiative (SBIRI) - that have been
a motivating factor for many small and medium enterprises (SMEs).
Says Dr Purnima Sharma, managing director, Biotech Consortium of India,
“SBIRI has opened new opportunities for innovation in the biotechnology
industry. Through this program, many successful examples of R&D and
commercialization of products have been witnessed.�
Further, the Indian Council for Medical Research (ICMR) has actively
supported clinical research, through its various initiatives and
facilities for microbial containment, pre-clinical toxicology units.
The
Department of Pharmaceuticals (DoP) has initiated efforts to establish
a large animal facility, compliant with good laboratory practices
(GLP), through the PPP route.
Besides these central government initiatives, various state
governments are promoting and providing incentives for the creation of
biotech parks.
R&D as a driver for PPP
In India, R&D retains its position as a key driver of the
biotechnology industry's success. Therefore, there is a strong need for
public private partnerships for nurturing and catalyzing R&D.
To provide an impetus to PPPs, the government has directed considerable
efforts, by supporting upstart firms with seed funds, through the New
Millennium Indian Technology Leadership Initiative (NMITLI) and Special
Drug Development Research Initiatives (SDDRI). This is, specifically,
to promote the flow of knowledge from national laboratories and
institutes to industry - for the development and commercialization of
technology. A total of six biotech parks are operational in
various states under the public private partnership, and 10 parks are
in different stages of development across the country.
"Let
private enterprise partner public science
and technology
institutions in their translation and transformational efforts. Let
them join hands with our public institutions, in creating new
manufacturing strategies for both strategic and non-strategic
applications. Let there be publicly-owned and privately-operated world
class R&D facilities.�
-
Dr
Manmohan
Singh,
Prime
Minister
of
India,
on
participation
of
private
sector
in
research
Focus on commercialization
The sharing of ideas, facilitating technology transfer and technical
expertise, form an important part of public private partnerships in
R&D. The CSIR-led institutes like National Chemical Laboratory
(NCL), Pune; Centre for Drug Research Institute (CDRI), Lucknow and
Institute of Microbial Technology (IMTECH), Chandigarh - are all at the
forefront of the public private partnerships.
IMTECH has collaborated with 32 companies including Ranbaxy, Cadila
Pharmaceuticals, Lupin and Panacea Biotech for various contract
research projects. Recently, CDRI, Lucknow has entered into a contract
research collaboration with Bangalore-based Biocon.
“There are many success stories related to drug development in CDRI,
with pharmaceutical industries in private and public sectors. Out of
the 16 new drugs/products developed in India, CDRI alone has a share of
11, which shows our important role,� says Dr Rajendra Prasad, head,
CDRI.
Innovation cannot be successful unless knowledge and information in any
R&D project are effectively shared. In this direction, virtual
teams provide an environment for flourishing innovation in R&D; and
bring about knowledge spillovers within enterprises, bridging time and
place; therefore, making them not a choice, but a requirement. The Open
Source Drug Discovery (OSDD) project by CSIR has been the biggest
initiative in this direction so far.
“The PPP remains one of the important needs of current times, and there
is a need for the industry to come forward and recognize the potential
of Indian scientists and their capabilities in R&D,� says Dr Rajesh
Gokhale, Director, Institute of Genomics & Integrative Biology
(IGIB).
A public private partnership can
play a vital role in addressing issues
during a pandemic; to make sure that innovations in biotechnology reach
the masses, when critically needed
At the onset of influenza A (H1N1)
pandemic, Department of
Biotechnology (DBT) took a unique initiative to nurture R&D and
innovation in biotechnology industry, under Biotechnology Industry
Research Assistance Programme (BIRAP).
DBT invited proposals from Indian
biotechnology companies for
indigenous development of a vaccine against influenza A (H1N1), under
the Biotechnology Industry Partnership Programme (BIPP).
Of the many applicants, New
Delhi-based Panacea Biotec was awarded the
financial assistance of
10
crore
for
the
development
of a vaccine. The
Pandyflu vaccine is all set to be launched soon.
Objectives: This grant of financial
assistance by Goverment of India,
through DBT, is in addition to a
10 crore grant of advance market
commitment (AMC) by Ministry of Health & Family Welfare (MoHFW).
The grant was given to Panacea Biotec to encourage development,
manufacture and supply of Pandyflu - a vaccine of paramount national
importance.
Success factors: As a result of
this partnership, Panacea Biotec will give the world an indigenously
produced Pandyflu - its vaccine against the H1N1 virus (swine flu).
The company developed the
conventional inactivated split virion vaccine
using egg-based technology, which is a sure shot path for developing
flu vaccine.
The company has more than 40 years
experience, and well established
regulatory pathways to ensure faster production of swine flu vaccine
matching international standards, to fulfill the global need.
Key Takeaways: The vaccine from
Panacea will increase options for the common public, to choose among
alternatives available in the market.
Panacea Biotec has set up a
state-of-the-art BSL2 level manufacturing
unit (high-containment facility) with BSL3 practices on its sprawling
campus, spread over 75 acres of land at Lalru (Punjab), for
manufacturing of Pandyflu vaccine. This facility has an annual capacity
to manufacture 45 million doses of the vaccine.
Way Forward: This type of PPP
initiatives to tackle the issue of national importance, should
certainly be repeated several times, so the benefit of biotechnology
innovation reaches the common people.
“I am
delighted
that the efforts of our scientists have again been recognized by
Government of India, by accepting our proposal; and grant of the said
assistance for such development.�
-
Mr Soshil Kumar Jain,
Chairman, Panacea Biotec
“The award
of
the financial assistance by the government reinforces the commitment to
promote innovation and public private partnership.�
-Mr Sumit Jain, Director Operations & Projects, Panacea Biotec
Overcoming barriers
Despite all success stories, there are certain outstanding issues that
need to be addressed. The streamlining of bureaucracy, bridging of
infrastructure and funding gap, regulatory requirements, tax and tariff
benefits; and most importantly, knowledge sharing in critical research
areas between industry and public institutes - are few issues requiring
attention.
Bt Brinjal to tackle pesticide bullets
The development of Bt Brinjal has
been an important achievement for the science community, but what it
also stands for, is a harmonious PPP
![](http://www.biospectrumindia.com/images/content/2010/Nov/shutterstock_11386168.jpg)
The Bt Brinjal was developed by the Maharashtra
Hybrid Seeds Company (Mahyco). The company used a DNA-construct
containing the cry1Ac gene, a CaMV 35S promoter, and the selectable
marker genes nptII and aad, to transform young cotyledons of brinjal
plants. A single copy elite event, named EE-1, was selected and
introduced into hybrid brinjal in Mahyco’s breeding program. Mahyco
then donated the Bt brinjal technology to Tamil Nadu Agricultural
University (TNAU), and University of Agricultural Sciences (UAS),
Dharwad. Later, the event EE-1 was back-crossed into open-pollinated
brinjal varieties.
Objectives: To create insect-
and insecticide-free brinjals for the benefit of farmers and consumers
in India. Also to foster collaboration between private sector and
public institutes, for cooperation in sharing of technological
knowledge.
Success factors: Bt brinjal
was found to be effective against Fruit and Shoot Borer (FSB), with 98
percent insect mortality in Bt brinjal shoots; and 100 percent in
fruits, compared to less than 30 percent mortality in non-Bt
counterparts. The Multilocation Research Trials (MLRTs) confirmed that
Bt brinjal required, on an average, 77 percent less insecticides than
non-Bt counterparts, for control of FSB, and 42 percent less, for the
control of all insect pests of brinjal.
Key Takeaways: The benefits of
Bt brinjal, translate to an average increase of 116 percent in
marketable fruits over conventional hybrids, and a similar increase
over popular open-pollinated varieties (OPVs). Furthermore, the
significant decrease in insecticide usage reduced the farmers’ exposure
to insecticides, and results, in a substantial decline in pesticide
residues in brinjal fruit (yield). The scientists have estimated that
Bt brinjal will deliver farmers a net economic benefit ranging from
![](http://www.biospectrumindia.com/images/content/2010/aug/INR-currency_symbol.jpg)
16,
299
to
![](http://www.biospectrumindia.com/images/content/2010/aug/INR-currency_symbol.jpg)
19,744
per
acre — with national benefits to India exceeding
![](http://www.biospectrumindia.com/images/content/2010/aug/INR-currency_symbol.jpg)
1700
crore
per year.
Bt brinjal has enormous potential to benefit both farmers and
consumers. The results of the studies submitted to regulatory
authorities in India confirm that Bt brinjal offers the opportunity to
provide effective control against FSB, and decrease insecticide input
by as much as 80 percent. Bt brinjal also yields significantly more
marketable fruit (yield) than conventional hybrids and open-pollinated
varieties.
Way Forward: The development
of Bt brinjal, the first biotech-vegetable crop in India, is an
appropriate and timely step, because it will further demonstrate the
significant benefits that biotechnology offers farmers, consumers and
India as a nation. The insect-resistant Bt brinjal hybrids and
varieties were developed through close and harmonious cooperation
between public and private research institutions. The joint
contribution of the two sectors is of critical importance, given that
national food security is a strategic issue. The adoption and
acceptance of Bt brinjal by farmers and consumers in India, will be a
highly significant event, that will enormously benefit the country and
the world.
One of the main barriers to PPP are apprehensions about the misuse of
proprietary material or knowledge, by the collaborators in a
partnership.
The high transaction costs of operationalization and coordination of
partnerships, mutual mistrust and negative perceptions have been major
hiccups for the collaborators. The inter-sectoral partnerships have
been able to deliver anticipated results in the form of advanced
researches, and acceptability by companies worldwide.
Future outlook
The PPP will play a fundamental role in the advancement of
biotechnology in the near future. Therefore, the hurdles coming in the
way of partnerships need to be addressed,
mutually by industry leaders and heads of public institutes. The
sharing of knowledge is a necessity, and more platforms should be built
for successful interaction and exchange of information between both
sides. However, it goes without saying that it is not only the duty of
government agencies to take this forward, but a larger participation of
the private sector is also essential.
--------------------------------------------------------------------------
Some of
the Public Private Partnerships in India
S
No. |
Company |
Public
Institutes |
1 |
Serum
Institute of India, Pune |
■ World
Health Organization (WHO) |
|
|
■ Health
Protection Agency (HPA) |
2 |
Panacea
Biotec, New Delhi |
■
National Institute of Immunology (NII) |
|
|
■
Jawaharlal Nehru University (JNU) |
|
|
■ Biotech
Consortium of India Ltd (BCIL) |
|
|
■
National Institute of Health, USA (NIH) |
3 |
Avesthangen |
■ National
Centre of Biological Sciences (NCBS) |
|
|
■
University of Agricultural Sciences (UAS) |
|
|
■ ICRISAT |
|
|
■ Imperial
College, London, UK |
4 |
Shantha
Biotechnics, Hyderabad |
■ Center
for Cell and Molecular Biology (CCMB) |
|
|
■ Indian
Institute of Science (IISc) |
|
|
■ Bhabha
Atomic Research Centre |
|
|
■
National Institute of Immunology (NII) |
|
|
■
Institute of Chemical Biology (IICB) |
|
|
■ Jawahar
Lal Nehru University (JNU) |
5 |
Rallis
India, Mumbai |
■
International Centre for Genetic Engineering and Bioltechnology (ICGEB) |
|
|
■ Indian
Institute of Science (IISc) |
|
|
■
University of Madurai |
|
|
■ World
Heath Organization |
6 |
Strand
Life Sciences, Bangalore |
■ Indian
Institute of Science (IISc) |
|
|
■ Council
for Scientific and Industrial Research (CSIR) |
|
|
■ Center
for DNA Fingerprinting & Diagnostics (CDFD) |
7 |
Syngene |
■ Indian
Institute of Science (IISc) |
|
|
■ Indian
Association of Cultivation of Sciences (IACS) |
8 |
Bharat
Biotech, Hyderabad |
■
Department of Biotechnology (DBT) |
|
|
■
International Centre for Genetic Engineering and Biotechnology (ICGEB) |
|
|
■ All
India Institute of Medical Sciences (AIIMS) |
9 |
Bangalore
Genei |
■ Center
for Cell and Molecular Biology (CCMB) |
|
|
■ Indian
Council for Agricultural research (ICAR) |
10 |
Monsanto
, Bangalore |
■ Indian
Institute of Science (IISc) |
|
|
■ The
Energy & Resource Institute (TERI) |
11 |
Wockhardt,
Mumbai |
■
International Centre for Genetic Engineering and Bioltechnology(ICGEB) |
12 |
Biocon,
Bangalore |
■ Central
Drug Research Institute(CDRI) |
|
|
■
Karolinska Institute, Sweden |
13 |
Life Care
Innovations |
■ Lucknow
Biotech Park |
|
|
■ Punjab
State Technical Council |
14 |
Transgene
Biotek |
■ Council
for Scientific & Industrial Research (CSIR) |
|
|
■ Indian
Universities |
Rahul Koul in New Delhi