Role of
biologicals in pandemic
The world is facing an
unprecedented threat from swine flu, caused by the now well-known H1N1
virus. Biological preparations can play a very effective role in
combating the situation
Initially, we saw some actions and some knee-jerk reactions to swine
flu threat. Initially, masks covering people’s faces in
cities and villages were a common sight. Later it seems to have given
way to complacency. Media reports on swine flu have also taken a break.
May be, the proverbial honeymoon period is over. Everyone is talking
about one particular anti-viral drug. We have no idea of the generic
name of the drug, but we hear about the brand names. Vaccines are being
developed and tried, so we hear about them. Fears of the
virus outsmarting the scientists by mutating are also aired.
The article is not being written forgetting the fact that vaccines are
also biologicals. In this context, it is worth spending a little time
on the mechanism of infections, and the way human body is dealing with
it. Any infection ultimately is cured by the body itself. Drugs
basically prevent the proliferation of the bacteria or virus and the
body takes over the rest. There is an eternal fight going on between
innumerable disease-causing organisms and our
body’s ‘army’. And in order to
keep us healthy or disease-free, these fighter cells with the help of
certain proteins and particular substances present in our blood and
body fluids are engaged to combat disease-causing organisms everyday.
If the battle is lost, we fall ill, and if our
‘army’ keeps winning, we remain healthy.
Biological preparations can play a very effective role in combating the
situation. Vaccines are the best bet. It is the best
preventive measure. It takes a little time to show the effect. There is
a gap between the introduction of the vaccine and its desired effect of
protection. This gap can be bridged by passive immunization.
To understand this situation, we need to go back to the basics of
immunology. This is intended only as a reminder to the readers. Any
infection, exposure or vaccination leaves the memory in our body with a
complex mechanism so that the system is pre-warned to circumvent any
such eventuality in future, and this is termed as immunity. The word
‘immune’ literally means
‘exempt’. That is to say, the process exempts us
from the vulnerability to the particular infective agent. The primary
immune response takes about a week to produce sufficient amount of
antibodies to neutralize, kill or eliminate the invading infectious
agents. This time, gap is taken care of by the use of drugs and medical
intervention. Antiviral or antibacterial drugs either kill or prevent
their replication.
This gap can be bridged by passive immunotherapy. Let us get familiar
with few of the complicated jargon scientists use. Starting with the
word ‘antigen’, generally, a foreign substance when
introduced knowingly or otherwise, is capable of starting an immune
response resulting in the production of
‘antibodies’. Antigens could be a whole
or parts of bacteria, viruses and fungi. While antibodies are
proteins capable of reacting against the particular antigens, which are
produced by the immune system of our body. They are very specific, and
that is the reason why we have to get all those injections for various
diseases. That is also the reason why we are waiting for a new vaccine
for swine flu which has to be very specific.
It is common knowledge among medical and biology students that the
immune response takes about a week, and in the meantime, passive
immunization can be the life saving measure. As a precaution, human
blood of healthy individuals containing these antibodies in a pure and
concentrated form can be used to ‘bridge’ the gap.
By that time, the body takes care of itself with the support of drugs
and medical care given. This method could substantially reduce the
complications. To be more specific, along with life support systems and
antiviral drugs, use of immune serum globulins or ready-made antibodies
can be effective. This is a well-known and proven method of treatment
for viral and bacterial infections.
Immunotherapy in conjunction with antibiotics or antiviral preparations
could be a good alternative. There are several such preparations for
intra-muscular and intra-venous administration. Probably, physicians
and policymakers can give this a thought. However, this line of
treatment is not mentioned by any media reports so far. Cost and the
efficacy of the available treatments may need closer examination and
evaluation. At the same time, there is nothing wrong in exploring this
line of treatment that is based on biologicals.
Scientific community should work on exploring the possibility of
alternative cheaper antiviral drugs, other systems of medicine and
newer lines of treatment. Swine flu is predicted to play long
innings.