IIT-M develops computational approach for maintaining good health and addressing diseases

July 25, 2023 | Tuesday | News

A computational approach to understand inter-organ communication network in humans

image credit- shutterstock

image credit- shutterstock

The Indian Institute of Technology Madras (IIT-M) scientists at the Robert Bosch Centre for Data Science and Artificial Intelligence (RBC-DSAI) have developed a computational approach called ‘MultiCens’ to understand the interactions between genes that are responsible for inter-organ communication within the body.

Communication among cells in different tissues and organs is pivotal to multicellular life. Molecular basis of such communication has long been studied, but genome-wide screens for genes and other biomolecules mediating tissue-tissue signaling are lacking.

To systematically identify inter-tissue mediators, IIT-M researchers developed ‘MultiCens’ (Multilayer/Multi-tissue network Centrality measures). The exchange of information between organs and tissues of the body is critical for the proper functioning and survival of all living organisms.

This inter-organ communication network (ICN) allows organisms to adapt to changes in their environment, assess their energy reserves, and maintain overall well-being. This research represents a significant advance in the development of methods to understand inter-organ communication and its implications.

Dr Ramanathan Sethuraman, Healthcare Architect and Principal Engineer at Intel and co-author of this work explained, “Understanding the molecular pathway for disease manifestation and to identify the causal targets are of prime importance in any disease management. MultiCens is a step in this research direction.”

 

Comments

× Your session has expired. Please click here to Sign-in or Sign-up

Have an Account?

Forgot your password?

First Name should not be empty!

Last Name should not be empty!

Email address should not be empty!

Show Password should not be empty!

Show Confirm Password should not be empty!

Newsletter

E-magazine

Biospectrum Infomercial

Bio Resource

I accept the terms & conditions & Privacy policy