09 March 2022 | News
Sentynl will acquire global rights to NULIBRY and will be responsible for the ongoing development and commercialisation in the US
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Sentynl Therapeutics, a US-based biopharmaceutical company and a wholly-owned subsidiary of Zydus Lifesciences announced the execution of an asset purchase agreement for the sale of BridgeBio’s NULIBRY (Fosdenopterin) for injection. NULIBRY is approved by the USFDA to reduce the risk of mortality in patients with molybdenum cofactor deficiency (MoCD) Type-A, an ultra-rare, life-threatening paediatric genetic disorder.
The company’s wholly-owned subsidiary Sentynl is also facilitating early diagnosis and treatment by enhancing awareness, new-born screening, genetic testing and patient support across multiple products and rare diseases including the development of a treatment for Menkes Disease, currently under rolling review by the USFDA, for which it partnered with Cyprium Therapeutics, (Cyprium).
Under the terms of the agreement, Sentynl will acquire global rights to NULIBRY and will be responsible for the ongoing development and commercialisation of NULIBRY in the US and developing, manufacturing and commercialising Fosdenopterin globally. BridgeBio will share development responsibilities for Fosdenopterin through approval of the marketing authorisation application already under accelerated assessment with the European Medicines Agency and through approval of its regulatory submission with the Israeli Ministry of Health. Sentynl will provide cash payments upon the achievement of certain regulatory milestones. BridgeBio will be eligible to receive commercial milestone payments as well as tiered royalties on adjusted net sales of NULIBRY.